Convinient Methylation process… | Talkchem.com
Convinient Methylation process…
Monday 20 July 2009 @ 8:02 pm

Found a convinient methylation process. Going to try out that agaisnt the one with methly iodide… Here is the process…

Gallacetophenone 3,4-dimethyl ether

To a boiling mixture of gallacetophenone (16.8g, 1 mol), benzene (400 mL) and anhydrous K2CO3 (55g) was added methyl sulphate (26.5g, 2.05 mol) in one portion, and the whole refluxed for 6 h with occasional shaking. After the addition of water (750 mL) and shaking, the benzene layer was separated and shaken several times with NaOH solution, and the alkaline extracts solidified. The precipitated gallacetophenone 3,4-dimethyl ether after crystallisation from MeOH had mp 75-77°C (yield 10g) (for previous methods of preparation from gallacetophenone, see Perkin9, Perkin and Wilson10, David and von Kostanecki11).

I found this interesting. I think it should be easier :) . The work up is much easier. No column atleast :D




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